Jambhekar, Sunil S and Philip J. Breen. 2012. Chapter 2: Extravascular Routes Of Drug Administration in Basic Pharamacokinetics, Second Edition. Pharmaceutical Press.
From the first page of the chapter:
Objectives Upon completion of this chapter, you will have the ability to:
• calculate plasma drug concentration at any given time after the administration of an extravascular dose of a drug, based on known or estimated pharmacokinetic parameters
• interpret the plasma drug concentration versus time curve of a drug administered extravascularly as the sum of an absorption curve and an elimination curve
• employ extrapolation techniques to characterize the absorption phase
• calculate the absorption rate constant and explain factors that influence this constant
• explain possible reasons for the presence of lag time in a drug’s absorption
• calculate peak plasma drug concentration, (Cp)max, and the time, tmax, at which this occurs
• explain the factors that influence peak plasma concentration and peak time
• decide when flip-flop kinetics may be a factor in the plasma drug concentration versus time curve of a drug administered extravascularly.
This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.
Keywords: pharamacokinetics,kinetics, drug, absorption, lag time, peak, concentration
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