2012-Jambhekar, Sunil S and Philip J. Breen - Chapter 2: Extravascular Routes Of Drug Administration in Basic Pharamacokinetics

By Brian Winkel

SIMIODE, Chardon OH USA

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Abstract

Jambhekar, Sunil S and Philip J. Breen. 2012. Chapter 2: Extravascular Routes Of Drug Administration in Basic Pharamacokinetics, Second Edition. Pharmaceutical Press.  

http://www.pharmpress.com/product/9780853699804/basic-pharmacokineticsutm_source=pharmpress&utm_medium=pdf&utm_campaign=sample_chapter . Accessed 8 September 2017.

From the first page of the chapter:

Objectives Upon completion of this chapter, you will have the ability to:

 • calculate plasma drug concentration at any given time after the administration of an extravascular dose of a drug, based on known or estimated pharmacokinetic parameters

• interpret the plasma drug concentration versus time curve of a drug administered extravascularly as the sum of an absorption curve and an elimination curve

 • employ extrapolation techniques to characterize the absorption phase

• calculate the absorption rate constant and explain factors that influence this constant

• explain possible reasons for the presence of lag time in a drug’s absorption

• calculate peak plasma drug concentration, (Cp)max, and the time, tmax, at which this occurs

• explain the factors that influence peak plasma concentration and peak time

• decide when flip-flop kinetics may be a factor in the plasma drug concentration versus time curve of a drug administered extravascularly.

This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.

Keywords:  pharamacokinetics,kinetics, drug, absorption, lag time, peak, concentration

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Researchers should cite this work as follows:

  • Brian Winkel (2017), "2012-Jambhekar, Sunil S and Philip J. Breen - Chapter 2: Extravascular Routes Of Drug Administration in Basic Pharamacokinetics," https://www.simiode.org/resources/3958.

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